Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni

Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni.

Adult Schistosoma mansoni parasites synthesize and secrete both cathepsin L and cathepsin B cysteine proteinases. These cysteine proteinase activities, believed to be involved in hemoglobin digestion by adult schistosomes, were characterized by using specific fluorogenic peptide substrates and zymography. Both cathepsin L- and B-like activities with pH optima of 5.2 and 6.2, respectively, predo...

Biochemical characterization of cathepsin D from adult Schistosoma mansoni worms.

Molecular characterization of a vacuolar processing enzyme related to a putative cysteine proteinase of Schistosoma mansoni.

Proproteins of various vacuolar proteins are post-translationally processed into mature forms by the action of a unique vacuolar processing enzyme. If such a processing enzyme is transported to vacuoles together with proprotein substrates, the enzyme must be a latent form. Immunocytochemical localization of a vacuolar processing enzyme, a 37-kD cysteine proteinase, in the endosperm of maturing ...

The cathepsin L-like proteinases of liver fluke and blood fluke parasites of the trematode genera Fasciola and Schistosoma.

J. R, Kerbel, R S., Khoo, N. and Lala, P. K. (I 993) Exp. Cell Res. 206,204-2 I I 4 I Morgan, M., Kniss, D. and McDonnell, S. (I 998) Exp. Cell Res. 242, 18-26 42 Kniss. D. A., Shubert P. J., Zimmerman, P. D., Landon, M. B. and Gabbe, S. G. ( 1994) J. Reprod. Med. 39,249-256 43 Matrisian, L M. ( I 993) Ann. N.Y. Acad. Sci. 732,42-50 44 Librach, C. L, Feigenbaum, S. L, Bass, K E., Cui, T. Y., Ve...

Characterization of the Ras homologue of Schistosoma mansoni.

Ras is a member of a super-family of guanine-binding or G-proteins. Ras functions as a molecular switch in the transduction of signals generated by the activation of a variety of cell surface receptors and relays the signals to downstream effectors. Little is known about signal transduction in schistosomes. In order for Schistosoma mansoni to survive different immune responses triggered by the ...